The hydrophobic core effect in model bacterial membranes upon interaction with tetra-p-guanidinoethylcalix[4]arene

The calixarene derivative used in this study (tetra-p-guanidinoethylcalix[4]arene) shows vitro activity against different Gram-positive and Gram-negative bacteria. interaction between bacterial cell membranes the water-soluble was investigated using model lipids spread as monomolecular films at air–water interface. Compression adsorption experiments, well Brewster angle microscopy, polarization modulation-infrared reflection–absorption spectroscopy computer modeling permitted understanding of intra- intermolecular several lipid-calixarene systems. Because affinity for may be linked to with negative charges, phosphatidylglycerols were lipids; contained saturated or unsaturated hydrocarbon chains lengths. It showed that monolayer depends on structure side chains. This observation interest a further development new antibiotics.